Our understanding of the nature, origin, and biological roles of double-stranded RNA found in fungi, plants, and animals has advanced greatly during the last five years. Because these genetic elements are capable of replication, they can be used to manage fungal diseases of crops, vegetables, turfgrass, fruit, and forest trees using genetic means rather than by environmentally hazardous chemicals. And recent evidence suggests that the presence of small amounts of dsRNA elicits sequence-specific gene silencing, which may lead to the development of treatments aimed at silencing harmful genes causing serious diseases in animals and humans.
dsRNA Genetic Elements: Concepts and Applications in Agriculture, Forestry, and Medicine compiles and unifies current knowledge of dsRNA genetic factors from different biological systems and discusses high-impact applications to agriculture, forestry, and medicine. It is a compilation of the latest advances on dsRNA systems from yeast, filamentous fungi, plants, and animals. This authoritative text is a valuable source of knowledge for a diverse audience from many areas of biology including molecular biology, genetics, and virology, as well as from applied fields in agriculture, forestry, and pharmaceutics.
Table of Contents
RNAi and Cosuppression: Double-Stranded RNA as an Agent of Sequence-Specific Genetic Silencing in Animals and Plants, Jeffrey A. Norman and Mary K. Montgomery
The Double-Stranded RNA-Activated Protein Kinase PKR, Randal J. Kaufman
The Double-Stranded RNA Viruses of Saccharomyces Cerevisiae, Reed B. Wickner, Juan Carlos Ribas, and Anjanette Searfoss
The Double-Stranded RNA Viruses of Ustilago Maydis and Their
Killer Toxins, Jeremy Bruenn
Molecular Basis of Symptom Expression by the Cryphonectria Hypovirus, Patricia M. McCabe and Neal K. Van Alfen
Engineering Hypoviruses for Fundamental and Practical Applications, Donald L. Nuss, Baoshan Chen, Lynn M. Geletka, Todd B. Parsley, and Nobuhiro Suzuki
Viruses of the Dutch Elm Disease Fungi, Kenneth W. Buck and Clive M. Brasier
Double-Stranded RNA Elements Modulating Virulence in Rhizoctonia Solani, Stellos M. Tavantzis, Dilip K. Lakshman, and Chunyu Liu
Molecular Genetics of the Viruses Infecting the Plant Pathogenic Fungus Helminthosporium Victoriae, Said A. Ghabrial, Ana I. Soldevila, and Wendy M. Havens
Unraveling the Viral Complex Associated with La France Disease
of the Cultivated Mushroom, Agaricus Bisporus, C.P. Romaine and M.M. Goodin
Large dsRNA Genetic Elements in Plants, Pierre Pfeiffer