1st Edition

Structure-Based Drug Design

ISBN 9780824798697
Published July 8, 1997 by CRC Press
664 Pages

USD $230.00

Prices & shipping based on shipping country


Book Description

Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!

Table of Contents


Inhibitors of HIV-1 Protease, Krzysztof Appelt
A Review of Structural Studies of HIV-1 Reverse Transcriptase and Implications for Drug Design, Jianping Ding, Kalyan Das, Prem N. S. Yadav, Yu Hsiou, Wanyi Zhang, Stephen H. Hughes, and Edward Arnold
Retroviral Integrase: Structure as a Foundation for Drug Design, Alison B. Hickman and Fred Dyda

Arthritis and Inflammation

Bradykinin Receptor Antagonists, Donald J. Kyle


Design of Purine Nucleoside Phosphorylase Inhibitors, Y. Sudhakara Babu, John A. Montgomery, Charles E. Bugg, W. Michael Carson, Sthanam V. L. Narayana, William J. Cook, Steven E. Ealick, Wayne C. Guida, Mark Erion, and John Secrist III
Structural Implications in the Design of Matrix-Metalloproteinase Inhibitors, John C. Spurlino
Structure - Function Relationships in Hydroxysteroid Dehydrogenases, Igor Tsigelny and Michael Baker
Design of ATP Competitive Specific Inhibitors of Protein Kinases Using Template Modeling, Janusz M. Sowadski, Charles A. Ellis, Rolf Karlsson, and Madhusudan

Diabetes Mellitis

Structural Studies of Aldose Reductase Inhibition, David K. Wilson, J. Mark Petrash, and Florante A. Quiocho

Heart Diseases

Structure-Based Design of Thrombin Inhibitors, Patricia C. Weber and Michael Czarniecki
Design of Antithrombotic Agents Directed at Factor Xa, William C. Ripka
Polypeptide Modulators of Sodium Channel Function as a Basis for the Development of Novel Cardiac Stimulants, Raymond S. Norton
Rational Design of Renin Inhibitors, V. Dhanaraj and J. B. Cooper

Parkinson's Disease

Structural Aspects in the Inhibitor Design of Catechol O-Methyltransferase, Jukka Vidgren and Martti Ovaska

Sleeping Sickness

Antitrypanosomiasis Drug Development Based on Structures of Glycolytic Enzymes, Christopher L. M. J. Verlinde, Hidong Kim, Bradley E. Bernstein, Shekhar C. Mande, and Wim G. J. Hol

Immune Diseases and Cytokines

Progress in the Design of Immunomodulators Based on the Structure of Interleukin-1, Glen Spraggon and Pandi Veerapandian
Structure and Functional Studies of Interferon: A Solid Foundation for Rational Drug Design, Michael A. Jarpe, Carol H. Pontzer, Brian E. Szente, and Howard M. Johnson


The Design of Anti-Influenza Virus Drugs from the X-Ray Molecular Structure of Influenza Virus Neuraminidase, Joseph N. Varghese
Rhinoviral Capsid-Binding Inhibitors: Structural Basis for Understanding Rhinoviral Biology and for Drug Design, Vincent L. Giranda and Guy D. Diana

Novel Methodologies

The Integration of Structure-Based Design and Directed Combinatorial Chemistry for New Pharmaceutical Discovery, Roger Bone and F. Raymond Salemme
Structure-Based Combinatorial Ligand Design, Amedeo Caflisch and Claus Ehrhardt
Peptidomimetic and Neopeptide Drug Discovery: Impact on Structure-Based Drug Design, Tomi K. Sawyer

View More


…Structure-Based Drug Design is an outstanding source of knowledge, inspiration, and delight. It is also a resonant proof that drug researchers are particularly fortunate scientists, being able to both uncover and contemplate the boundless complexities of Nature, and to actualize their awe by contributing to general health and well-being.
"-Journal of Pharmaceutical Research

"…the book is well-planned and executed, succeeding in giving the reader a fairly broad and complete overview of the many facets of structure based drug design.
"-Journal of Medicinal Chemistry