1st Edition

Pharmacology of Cerebral Ischemia



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ISBN 9780849310218
Published November 1, 2001 by Medpharm
541 Pages

USD $200.00

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Book Description

Discussing state of the art techniques and the latest development in the field, Pharmacology of Cerebral Ischemia forges links between basic science and practical therapy.

Table of Contents

Apoptosis and Necrosis After Ischemia
Apoptosis and Neurodegeneration: Role of Caspases, P. Nicotera
Apurinic/Apyrimidinic Endonuclease Expression and Oxidative Stress in Apoptosis after Transient Focal Cerebral Ischemia, M. Fujimura, Y. Morita-Fujimura, M. Kawase, Y.-Y. Chang, and P.H. Chan
A Role for the Transcription Factor E2F1 in Experimental Stroke Damage, J.P. MacManus, S.T. Hou, M. Jian, E. Preston, J. Webster, and B, Zurakowski
Reactive Oxygen and Cytochrome C Release in Neuronal Apoptosis, R.A. Kirkland and J.L. Franklin
The Roles of Beta-Amyloid Percursor Protein and Amyloid Beta Peptide in Ischemic Brain Injury, B. Lin and M.D. Ginsberg
Receptors and Intracellular Signaling
A Possible Role for Tachykinins in Stroke, R.K. Stumm, C. Culmsee, C. Schaper, M.K.-H. Scafer, J. Krieglstein, and E. Weihe
New Insights into the Role of NMDA-Receptors and Nitric Oxide Formation in the Genesis of Spreading Depression, T.P. Obrenovitch
Imaging the Anoxic Depolarization, a Multifocal and Propagating Event, R.D. Andrew, T.R. Anderson, A.J. Biedermann, I. Joshi, and C.R. Jarvis
Protein Phosphatases and Neuronal Apoptosis, S. Klumpp, D. Selke, and J. Krieglstein
Role of Cyclin Dependent Kinases in Neuronal Death, D.S. Park
p21 ras/Erk-Dependent Signaling Activates Ischemic Tolerance, V.L. Dawson and T.M. Dawson
Neuroprotective Potency of Activated NF- B, C. Kaltschmidt and B. Kaltschmidt
NF- B is Activated and Promotes Cell Death in Focal Cerebral Ischemia, A. Schneider, A. Martin-Villalba, F. Weih, J. Vogel, T. Wirth, and M. Schwaniger
Caspases in Cerebral Ischemia, N. Plesnila and M.A. Moskowitz
Intrinsic and Extrinsic Pathways of Caspase Activation in Cerebral Ischemia, K. Jin, J. Chen, and R.P. Simon
Mechanisms of Neuronal Cell Injury: Does Endoplasmic Reticulum Dysfunction Play a Special Role? W. Paschen
Role of Mitochondria in Neuronal Cell Death
The Role of Mitochondrial Dysfunction in Reperfusion Damage of the Brain, B.K. Siesjö, T. Kristián, F. Shibasaki, and H. Uchino
Mitochondria as Targets of Neuroprotection by Bcl-2 Family Proteins, G. Fiskum, B.M. Polster, and A.J. Kowaltowski
Regulation of Active Cell Death in Ischemic Brain Injury: The Role of Bax and the Mitochondrial Pathway, J. Chen and X.M. Yin
The Effect of pH on State 3 and State 4 Brain Mitochondrial Metabolism, D.B. Kintner, K.A. Sailor, and D.D. Gilboe
Cytochrome C Release in Apoptotic and Excito-Toxic Neuron Death, J.H.M. Prehn, N.T. Bui, A.J. Krohn, C.M. Luetjens, M. Poppe, and C. Reimertz
Regulation of the Mitochondrial Permeability Transition Pore by Ubiquinone Analogs, P. Bernardi and E. Fontaine
Inflammation and Neuronal Cell Death
Do Caspase and Proteasome Inhibitors Influence the Delayed Maturation of Cortical Infarction by Preventing Apoptosis or Neuroinflammation? A.M. Buchan
Inflammation-Related Genes and Ischemic Brain Injury, C. Iadecola, M. Alexander, S. Nogawa, E. Araki, and M.E. Ross
Metalloproteinase Generation and Matrix Injury During Focal Cerebral Ischemia, G.J. del Zoppo, J. Lucero, N. Hosomi, and J.H. Heo
Inhibition of Inflammation and Neuroprotection by Tetracyclines, J. Yrjänjeikki, T. Tikka, G. Goldsteins, M. Koistinaho, R. Keinänen, P.H. Chan, and J. Koistinaho
Non-Neuronal Cells in the Injured Brain: Cellular Pathology and Molecular Activation Signals, G. Raivich
Ultrastructural Behavior of Astrocytes to Singly Dying Cortical Neurons, U.Ito, T. Kuroiwa, S. Hanyu, Y. Hakamata, S. Ito, I. Nakano, and K. Oyanagai
Circulation
Dynamic Investigation of the Rat Cortical Microcirculation Using Confocal Videomicroscopy in Transient Focal Ischemia and Related Penumbral Depolarizations, H. Nallet, S. Roussel, O. Isseratial, E.T. MacKenzie, J. Seylaz, and E. Pinard
Cerebral Vasospasm of Penetrating Arteries in Brain Stem, A.Y. Zubkov and J.H. Zhang
Repair, Recovery, and Neuroprotection
DNA Damage and Repair in the Setting of Mild Injury, H.-M. Lee, G.H. Greeley,Jr., and E.W. Englander
Functional Recovery after Brain Injury: Role of Neurotrophic Factors and Behavior-Driven Structural Events, T. Schallert, S.T. Bland, and S.M. Fleming
Difference in the Time Windows for the Induction of Ischemic Tolerance: Putative Mechanisms, M.A. Pérez-Pinzón
The Neuroprotective Efficacy of Human Serum Albumin Therapy in Focal and Global Cerebral Ischemia and Traumatic Brain Injury, M.D. Ginsberg, L. Belayev, W. Zhao, Y.Liu, E. Pinard, J. Seylaz, H. Nallet, and R. Busto
Growth Factors and Cytokines
Update on Growth Factor Treatment for Stroke: 2000, S.P. Finklestein and K. Wada
Gene Transfer of GDNF Ameliorates Ischemic Rat Brain Injury after Transient MCA Occlusion, K. Abe, H. Kitagawa, and T. Hayashi
The Expression Pattern of TGF- 1 in Rat Hippocampus after Transient Forebrain Ischemia and after Stimulation of 2-Adrenoceptors, Y. Zhu and J. Kreiglstein
Modulation of the Serpine/Serine Proteases Axis by TGF- 1 is a Key Element in the Control of the Glutamatergic Neurotransmission, D. Vivien, C. Ali, O. Nicole, F. Docagne, and A, Buisson
Contextual Actions of TGF- and Cytkine Signaling Pathways in Mediating Neurotrophic Functions, N. Schuster, A. Schober, and K. Kreiglstein
Cytokines as Therapeutic Targets in Stroke, N.J. Rothwell
Inflammatory and Anti-Inflammatory Cytokines and Neuronal Cell Death, S.A. Loddick
Site-Specific Actions of Interleukin-1 in Neurodegeneration, S.M. Allen, L.C. Parker, R.I Grundy, and B. Collins
Genes and Gene Therapy
Expression Analysis and Functional Genomics for Brain Research: Expression Profiling in a Mouse Model for Huntington's Disease, W. Nietfeld, J. Schuchhardt, A. Malik, N. Tandon, E. Rohlfs, E.E. Wanker, H. Eickhoff, and H. Lehrach
High Throughput Transcript Profiling: An Assessment of SAGE in the Context of Stroke Research, G. Trendelenburg and U. Dirnagl
The Role of Gene Therapy in Acute Cerebral Ischemia, M.A. Yenari, T.C. Dumas, R.M. Sapolsky, G.K. Steinberg
Stem Cell Therapy and Neurogenesis
Neurogenesis and Synaptogenesis in Hippocampus Following Global Ischemia, R. Bernabeu, J. Liu, and F.R. Sharp
Treatment if Neural Injury with Bone Marrow, M. Chopp, Y. Li, and J. Chen
Harnessing Neural Stem Cell Biology to Compensate for Cerebral Ischemic Injury, K.I. Park, B.A. Tate, J.M. Ren, D. Sietsma, A. Marciniak, S.P. Finklestein, and E.Y. Snyder
Possible Transplantation Strategies in Stroke: Could Stem Cells be the Answer? C.N. Svendsen
Predictiveness of Animal Models for Clinical Trials
Translating Experimental Neuroprotection to Humans: Failure and Success, J. Grotta
Which Pathophysiologic Mechanisms are Relevant Therapeutic Targets in Ischemic Stroke? W.-D. Heiss, L.W. Kracht, A. Thiel, M. Grond, G. Pawlik, and R. Graf
Pathophysiology of Thrombolytic Reperfusion Versus Reversible Thread Occlusion of Middle Cerebral Artery in Mice, T. Hara, R. Hata, G. Miles, and K.-A. Hossmann

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