1st Edition

Pharmacokinetic Analysis
A Practical Approach



ISBN 9781566764254
Published June 7, 1996 by Routledge
568 Pages

USD $385.00

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Book Description

This insightful work provides a useful introduction to the very large and important field of pharmacokinetics. The authors have selected the Time Constant Approach as a unifying view within which to present important application areas. In addition to providing consistency, their approach provides the novice with an intuitive time view that is meaningful from the outset. This approach allows one to get a "feel" for the data and to relate it to other data in a direct and accessible manner.

The Time Constant Approach provides a synthesis of the noncompartmental and compartmental methods, with the advantages of both. It starts by defining a physiologically meaningful model based on the pharmacokinetic processes involved. The Time Constant Approach recognizes pharmacokinetics as a number of processes that move drugs between physiological compartments, each process occurring at its own characteristic length of time, to correlate descriptive pharmacokinetic events with time constants of pharmacokinetic processes. While analogous to the three most common testing approaches for pharmacokinetics (the noncompartmental, compartmental and statistical moment approaches) the Time Constant Approach possesses many advantages.

Table of Contents

Section I: Basics and Methods * Introduction


Time Constant Approach

Evaluation of Time Constants by Visual Inspection of Concentration

Time Profiles

Scaling of Time Constants Among Different Animal Species


Section II: Formulation Factors
Influence of Administration Route on Pharmacokinetics

Bioavailability

Influence of Formulation on Pharmacokinetics

Bioequivalence

Influence of Dosage on Pharmacokinetics

Dose Proportionality

Pharmacokinetics of Sustained Release and Immediate Release Formulations


Section III: Absorption, Distribution, Metabolism, and Pharmacodynamics * Absorption of Drugs in Gastrointestinal Tract


Drug Distribution into Tissue

Tissue Penetration

Pharmacokinetics of Metabolites

Relationship between Pharmacokinetics and Pharmacodynamics


Section IV: Interactions
Influences of Food on Pharmacokinetics

Effects of Drug Interactions on Pharmacokinetics


Section V: Special Population
Influence of Age on Pharmacokinetics

Difference in Pharmacokinetics between Genders

Special Pharmacokinetic Considerations in Renal Impairment

Special Pharmacokinetic Considerations in Hepatic Impairment

Special Pharmacokinetic Considerations in Other Diseases


Appendices:
Derivation of Mean Residence Time from Input and Output Times

Derivation of AUC and AUMC Using Laplace Transform

Derivation of AUC and AUMC in the Pharmacokinetic Models

Index

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