Neuroscience research in alcohol-related disorders has made remarkable progress in the last two decades. The advances are due, in great part, to the large array of powerful biomedical, bioengineering, and computational biological techniques that are now employed.
To date, there has not been a comprehensive text that covers recently developed methods in alcohol-related research. Methods in Alcohol-Related Neuroscience Research provides up-to-date technical guidance for investigators doing research at the molecular, cellular, systems, and behavioral levels. These techniques include a wide variety of approaches, ranging from gene mapping and examination of molecular interactions of alcohol at the sub-cellular level to recording of neural activities in freely-behaving animals and imaging alcohol effects on the living human brain.
Written by a panel of experts, Methods in Alcohol-Related Neuroscience Research not only provides information of a technical nature but also gives an overview of the many areas in investigating the effects of alcohol on the brain.
Table of Contents
Quantitative Trait Locus (QTL) Mapping in Mice, A.A. Palmer and T.J. Phillips
Knockout and Knockin Mice, G.E. Homanics
Molecular Studies by Chimeragenesis and Mutagenesis, M.J. Beckstead, G.F. Lopreato, K.E. Vrana and S.J. Mihic
Combining Patch-Clamp Recording and Gene Profiling in Single Neurons, H.H. Yeh, S. Therianos and S.-M. Lu
Quantitative Analysis of Neurotransmitter Receptor Expression with Antibody-Based Techniques, C.F. Valenzuela and D.D. Savage
Artificial Bilayer Techniques in Ion Channel Study, S.N. Treistman, R. O'Connell and J. Crowley
Rapid Drug Superfusion and Kinetic Analysis, D.M. Lovinger, S. Sikes and Q. Zhou
Electrophysiological Assessment of Synaptic Transmission in Brain Slices, J.L. Weiner
Cognitive Correlates of Single Neuron Activity in Task-Performing Animals, B. Givens and T.M. Gill
Multichannel Neural Ensemble Recording During Alcohol Self-Administration, P.H. Janak
Combined Single-Neuron Recording and Microdialysis in the Brain of Freely Behaving Animals (Rodents and Non-Human Primates), N. Ludvig
Quantitative Microdialysis for in vivo Studies of Pharmacodynamics, R.A. Gonzales, A.Tang, and D.L. Robinson
Structural Magnetic Resonance Imaging (MRI) of the Human Brain, T.L. Jernigan
Biochemical, Functional and Microstructural Magnetic Resonance Imaging (MRI), E. Adalsteinsson, E.V. Sullivan and A. Pfefferbaum