This up-to-the-minute and comprehensive resource lucidly covers gene therapy for lung diseases from existing technologies delivering foreign DNA to the lungs via the airways or circulation to promising new approaches for the further development of safe and efficient gene delivery systems.
Table of Contents
Human Gene Therapy: The Initial Concepts, W. French Anderson
Discovering Genes That Cause Disease, Francis S. Collins
Delivering Genes to Human Lungs
Adenoviral Vectors for Gene Therapy of Inherited and Acquired Disorders of the Lung, David T. Curiel and Robert I. Garver, Jr.
Adeno-Associated Virus-Based Delivery Systems, Pamela L. Zeitlin
Cellular Responses to Adenovirus Entry, Susanna Chiocca and Matthew Cotton
Catonic Lipid-Based Gene Delivery: An Update, Xiang Gao
Liposome/Viral Hybrid Gene Delivery Systems, Arlene A. Stecenko
Gene Therapy in the Lung: The Next Generation
Manipulating the Intracellular Trafficking of Nucleic Acids, Kathleen E. B. Meyer, Lisa S. Uyechi, and Francis C. Szoka, Jr.
Delivery of Genes Through the Lung Circulation, David M. Rodman and Elizabeth G. Nabel
Targeting Gene Expression to the Lung, Jeffrey A. Whitsett and Stephan W. Glasser
Strategies to Accomplish Targeted Gene Delivery Employing Tropism-Modified Adenoviral Vectors, Joanne T. Douglas and David T. Curiel
Disease-Directed Gene Therapy
Toward Correction of the Genetic Defect in Cystic Fibrosis, Larry G. Johnson and Richard C. Boucher
Correction of the Genetic Defect in Alpha-1 Antitrypsin Deficiency by Somatic Gene Therapy, Randy C. Eisensmith and Savio L. C. Woo
Gene Therapy for Chronic Inflammatory Diseases of the Lungs, Angelo E. Canonico
Gene Therapy for Acute Diseases of the Lungs, Kenneth L. Brigham
Gene Therapy for Lung Cancer, Choon-Taek Lee and David P. Carbone
The Regulatory Process and Gene Therapy, Suzanne Epstein
Some Issues Affecting Progress Toward Human Gene Therapy and Potential Application to the Lung, Theodore Friedmann