1st Edition

Drug Resistance in Oncology




ISBN 9780824792954
Published August 20, 1997 by CRC Press
416 Pages

USD $235.00

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Book Description

This timely new reference integrates the latest clinical results and laboratory studies on the resistance of specific cancers to chemotherapeutic drugs-covering drug resistance in lung, breast, ovary, and colon cancer as well as hematological malignancies.

Table of Contents

Respiratory Cancer

Chemotherapy Resistance in Small Cell Lung Cancer: Consequences for the Clinician and Future Prospects, Bonne Biesma, Egbert F. Smit, and Pieter E. Postmus
Multidrug Resistance in Small Cell Lung Cancer, Shelagh E. L. Mirski and Susan P. C. Cole
Correlations Between Clinical Outcomes and In Vitro Chemosensitivity Testing in Non-Small Cell Lung Cancer (NSCLC), David W. Wilbur
Liposomal Formulations of Chemotherapeutic Drugs, Samuel D. Bernal, Yuk-Chor Wong, Romulo de Villa, and Gloria Bernas

Breast Cancer

Tamoxifen Resistance and Breast Cancer, Lin Soe and Michael W. DeGregorio
Breast Cancer Resistance to Endocrine Therapy, Per E. Lønning
Heat Shock Proteins and Drug Resistance in Breast Cancer, Daniel R. Ciocca and Laura M. Vargas Roig

Other Epithelial Cancers

Overcoming Drug Resistance in Ovarian Cancer, P. H. B. Willemse, G. J. Veldhuis, A. G. J. van der Zee, and E. G. E. de Vries
Protein Kinase C Activation and the Intrinsic Drug Resistance of Human Colon Cancer, Catherine A. O'Brian, Karen R. Gravitt, Nancy E. Ward, Krishna P. Guta, Philip J. Bergman, and Constantin G. Ioannides

Hematological Malignancies

Clinical Relevance of P-Glycoprotein-Related Multidrug Resistance in Hematological Malignancies, Petra C. Pasman and Harry C. Schouten
Prediction of Cytotoxic Drug Resistance in Acute Leukemia, Rolf Larsson

Mechanisms of Drug Resistance

Determinants of Estramustine Resistance, Lisa A. Speicher and Kenneth D. Tew
Strategies for Overcoming Anthracycline Resistance, Daniel J. Booser
Cellular Mechanisms of Cisplatin Resistance, Jeroen Oldeburg and Gerrit Los
Radiation Response in Chemotherapy-Resistant Tumors, Patrick Miller, Michael Nejad, and David S. Shimm
Preclinical In Vivo Models of Drug Resistance, Beverly A. Teicher

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Reviews

"
…this book is a very timely update on mechanisms of drug resistance. It is quite comprehensive and is recommended for the clinician engaged in clinical research to whom it will provide an excellent review on the subject.
"-ASCO OnLine