1st Edition

Carbon Monoxide and Cardiovascular Functions

ISBN 9780849310416
Published October 30, 2001 by CRC Press
336 Pages 60 B/W Illustrations

USD $290.00

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Book Description

Akin to nitric oxide, carbon monoxide (CO) was initially viewed as a pure toxic gas, yet it has been recently demonstrated to be an important endogenous molecule of gas that has profound physiological and pathophysiological effects on the cardiovascular system. In spite of the growing understanding achieved in this field, until now a comprehensive book summarizing the extraordinary advances in the research of the cardiovascular effects of CO has not been available.

Carbon Monoxide and Cardiovascular Functions responds to the vexing challenges and exciting opportunities that confront researchers and clinicians studying the biological roles of CO in the cardiovascular system. This book presents many never-before-published results including the first case of human CO deficiency. It also discusses disorders where the cardiovascular effects of CO might have been altered, including hypertension, diabetes, stroke, and ischemic heart damage.

A product of the collected knowledge of internationally respected scientists, this book serves as a standard reference summarizing recent developments, scientific controversies, and future directions in the study of the biological actions of CO on the cardiovascular system. By covering both ancient and state-of-the-art methodologies in great detail, Carbon Monoxide and Cardiovascular Functions, affords a rapid mastery of the powerful new advances in CO study.

Table of Contents


The Physiological Role of Carbon Monoxide Derived from Heme Oxidation Catalysed by Heme Oxygenase, Gerald S. Marks, Brian E. McLaughlin, James F. Brien, and Kanji Nakatsu

Carbon Monoxide-Induced Vasorelaxation and the Underlying Mechanisms, Weimin Zhao and Rui Wang

Carbon Monoxide and Vascular Smooth Muscle Cell Growth, William Durante

Signal Transduction Pathways Involved in CO-Induced Vasodilation: The Role of Cyclic GMP/Soluble Guanylyl Cyclase, Kanji Nakatsu, James F. Brien, Brian E. McLaughlin, and Gerald S. Marks

Carbon Monoxide, Vascular Contractility, and K+ Channels, Kun Cao and Rui Wang

Nitric Oxide and the Heme Oxygenase/Carbon Monoxide System: Cooperation in the Control of Vascular Function, Roberta Foresti, Colin J. Green, and Roberto Motterlini

Developmental Biology of Heme Oxygenase and Carbon Monoxide in the Cardiopulmonary System, Phyllis A. Dennery

Carbon Monoxide Signaling in the Heart, Dipak K. Das and Nilanjana Maulik


The Heme-Heme Oxygenase-Carbon Monoxide System and Hypertension, Robert A. Johnson and Fruzsina K. Johnson

Carbon Monoxide and Cardiovascular Inflammation, Joseph Fomusi Ndisang, Emanuela Masini, Pier Francesco Mannanoni, and Rui Wang

Human HO-1 Deficiency and Cardiovascular Dysfunction, A. Yachie, A. Kawashima, K. Ohta, Y. Saikawa, and S. Koizumi

The Roles of Carbon Monoxide in the Pathogenesis of Diabetes and Its Vascular Complications, Lingyun Wu and Rui Wang

Selective Increase in Human Heme Oxygenase-1 Gene Expression Attenuates Development of Hypertension and Increases Body Growth in Spontaneously Hypertensive Rats, Nader G Abraham, Shuo Quan, Sylvia Shenouda, and Attallah Kappas


Studies on the Development of Carbon Monoxide-Releasing Molecules: Potential Applications for the Treatment of Cardiovascular Dysfunction, Roberto Motterlini, Roberta Foresti, and Colin J. Green

Sources, Sinks, and Measurement of Carbon Monoxide, Hendrik J. Vreman, Ronald J. Wong, and David K. Stevenson

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"The book gives a first rate summary of the mechanisms by which CO exerts its action on vascular smooth muscle…The illustrations and pertinent data are well organized and clear. The book is a good source for graduate or upper division undergraduate courses in pharmacology, physiology, or biochemistry of CO. To my knowledge there are no other books in this subject. 3 stars."
- John Buchholz, Ph.D., Loma Linda University, Doody's Notes